This dataset provides information on the catches of large sharks in the Shark River Slough in relation to physical factors including dissolved oxygen, water temperature, salinity, and distance upstream. Analysis of data collected suggest that distance from the Gulf of Mexico and salinity have the largest effects on shark catch rates, with most large sharks being caught at the mouth of the estuary in high salinity waters. This dataset includes all sharks caught on drumline gear, including large coastal species such as bull sharks and lemon sharks, as well as smaller coastal species such as Atlantic sharpnose sharks and blacknose sharks.