Wetlands provide essential ecosystem services, including nutrient cycling, flood protection, and biodiversity support, that are sensitive to changes in wetland hydrology. Wetland hydrological inputs come from precipitation, groundwater discharge, and surface run-off. Changes to these inputs via climate variation, groundwater extraction, and land development may alter the timing and magnitude of wetland inundation. Data were compiled for 152 wetlands in west-central Florida over 14 years to investigate the response of wetland inundation to the interactive effects of precipitation, groundwater extraction, surrounding land development, basin geomorphology, and wetland vegetation class. Further methods are defined in the Methods section of the journal article associated with this dataset (Synergistic effects of precipitation and groundwater extraction on freshwater wetland inundation, published in the Journal of Environmental Management, 2023).