Arctic coastal erosion mobilizes large quantities of permafrost organic matter to the Arctic Ocean, where it may be decomposed, releasing carbon dioxide. To quantify the biodegradability of this eroding material, we designed an aerobic bottle incubation experiment to measure CO2 production from coastal soils/sediments submerged in seawater. Seasonally thawed active layer soils and permafrost were sampled near Drew Point along the Alaska Beaufort Sea coast. Cores were taken from three surface geomorphic classifications common in this area: primary surface that has not been reworked by thaw-lake cycles, a young drained lake basin, and an ancient drained lake basin. Core subsamples were chosen to represent three distinct horizons present in eroding bluffs at Drew Point: seasonally thawed active layer soils near the tundra surface, Holocene-age terrestrial soils and/or lake sediments, and late-Pleistocene age relict marine sediments. Soil/sediment subsamples were mixed with Beaufort Sea surface water and incubated in triplicate at 4C and 16C for 40 days. In addition, a subset of soil/sediment samples were incubated with and without seawater at 16C for 40 days. The data reported here summarizes the results of the incubation experiment for each soil sample: cumulative CO2-C production over 40 days normalized to dry weight and to organic carbon content (OC), average rate of CO2 production normalized to dry weight and to TOC, and the percent of OC remineralized over 40 days.