The LAGOS-US LAKE DEPTH v1.0 module (hereafter, called DEPTH) contains in situ measurements of lake depth for a subset of all lakes (n = 17,675) in the conterminous U.S. > 1 ha (3.7% of 479,950) that are in the LAGOS-US LOCUS v1.0 data module (Smith et al. 2021). All 17,675 lakes in DEPTH have a maximum depth value and 6,137 lakes have a mean depth. DEPTH includes approximately 65 data sources obtained from community, government, and university monitoring programs, as well as academic reports and commercial websites. DEPTH includes lake identifiers, lake location, lake area, lake depth (both maximum and mean depth when available), source information, and data flags. The unique lake identifier (lagoslakeid) for all lakes is the same one used in LAGOS-US LOCUS v1.0.